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norskBlar i forfatter "Stuge, Tor Brynjar"
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Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: A laboratory study using an in vitro model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-21)Background: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are accountable for the majority of FNAIT cases. We have previously shown that high levels of maternal anti-HPA-1a antibodies are associated with clinically significant reduced birth ... -
Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-12)Accumulating evidence supports the notion that high-dose (>5 Gy) radiotherapy (RT) regimens are triggering stronger pro-immunogenic effects than standard low-dose (2 Gy) regimens. However, the effects of RT on certain immunoregulatory elements in tumors remain unexplored. In this study, we have investigated the effects of high-dose radiotherapy (HD-RT) on the immunomodulating functions of cancer-associated ... -
Current perspectives on fetal and neonatal alloimmune thrombocytopenia - Increasing clinical concerns and new treatment opportunities
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-19)Differences in platelet type between the fetus and the mother can lead to maternal immunization and destruction of the fetal platelets, a condition named fetal and neonatal alloimmune thrombocytopenia (FNAIT). FNAIT is reported to occur in ~1 per 1,000 live born neonates. The major risk is intracranial hemorrhage in the fetus or newborn, which is associated with severe neurological ... -
The prevalence of HPA-1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR-DQ haplotypes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-16)Alloimmunization against human platelet antigen (HPA)-1a during pregnancy can cause foetal/neonatal alloimmune thrombocytopenia (FNAIT) and severe bleeding in the foetus or newborn and likely depends on several factors. HPA-1a alloimmunization is associated with <i>DRB3*01:01</i>, which is associated with several DR-DQ haplotypes. However, it is not known to what extent these haplotypes contribute ... -
Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-01)Maternal alloantibodies toward paternally inherited Ags on fetal platelets can cause thrombocytopenia and bleeding complications in the fetus or neonate, referred to as fetal and neonatal alloimmune thrombocytopenia (FNAIT). This is most commonly caused by Abs against the human platelet Ag (HPA)-1a in Caucasians, and a prophylactic regimen to reduce the risk for alloimmunization to women at risk ... -
Storage-induced platelet apoptosis is a potential risk factor for alloimmunization upon platelet transfusion
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-05)Platelet transfusion can elicit alloimmune responses leading to alloantibody formation against donor-specific polymorphic residues, ultimately resulting in platelet transfusion refractoriness. Universal leukoreduction significantly reduced the frequency of alloimmunization after platelet transfusion, thereby showing the importance of white blood cells (WBCs) in inducing this alloresponse. It is, ...
